Blood rune

Blood runes are the second highest level runes, behind Soul runes, and the most valuable runes of all. They are used in the highest level spells, the lowest of which being Ruby Crossbow Bolt Enchant, and the highest being Ice Barrage.

Blood runes can be made with the runecrafting skill at 77 Runecrafting with dark essence fragments, and gain 23 experience per dark essence fragment. It is possible to reach approximately 38,000 experience per hour.

Note: Using full Graceful outfit and having at least 77 agility are enough to have enough run energy to last the whole trip.

Obtaining
Blood runes can be obtained in various ways, including: Since Zeah's release players can now Runecraft Blood runes at 77.
 * Purchase from various Rune shops, including:
 * Magic Guild shop
 * Ali Morrisaine's Runeshop (after The Feud quest and part of Rogue Trader mini-quest)
 * Looting from the Barrows' Chest
 * Thieving from the Chaos Druid's Tower chest (requires level 59 Thieving)
 * As drops from various monsters
 * Spawns in level 36 wilderness in the middle of the venomous spiders

Spells that require blood runes
Blood runes are used in all of the following spells in the Standard spellbook:
 * Enchant Ruby Crossbow Bolts (Level 49)
 * Saradomin Strike (Level 60)
 * Claws of Guthix (Level 60)
 * Flames of Zamorak (Level 60)
 * Wind Wave (Level 62)
 * Water Wave (Level 65)
 * Earth Wave (Level 70)
 * Fire Wave (Level 75)
 * Charge (Level 80)

The Ancient spellbook makes extensive use of Blood runes, and they are used in exactly half of all Ancient spells:
 * Blood Rush (Level 56)
 * Kharyrll Teleport (Level 66) (Canifis)
 * Blood Burst (Level 68)
 * Smoke Blitz (Level 74)
 * Shadow Blitz (Level 76)
 * Blood Blitz (Level 80)
 * Ice Blitz (Level 82)
 * Smoke Barrage (Level 86)
 * Shadow Barrage (Level 88)
 * Annakarl Teleport (Level 90) (Demonic Ruins)
 * Blood Barrage (Level 92)
 * Ice Barrage (Level 94)

The Lunar spellbook uses Blood runes only in its healing spells:
 * Heal Other (Level 92)
 * Heal Group (Level 95)

The Necromancy spellbook uses Blood runes in the higher level reanimation spells:
 * Reanimate TzHaar (Level 69)
 * Reanimate Demon (Level 72)
 * Reanimate Aviansie (Level 78)
 * Reanimate Abyssal Creature (Level 85)
 * Reanimate Dragon (Level 93)

Dropping Monsters

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