Demons are a category of creature characterized by a beastly appearance, and often a red or black colouration. A wide variety of creatures are encompassed in this category, including many which are not explicitly referred to as demons in-game. Some demons are considered sub-classes of other varieties, and thus will count towards a Slayer assignment for the primary class. These cases are labelled in parenthesis.
- Lesser demon
- Greater demon
- Black demon
- Abyssal demon
- Ice demon
- Demonic gorilla (Black demon)
- "Fiend" type monsters are considered a subclass of demons. Arclight and its variants as well as Holy water do not work against them.
- As with all revenants, Salve amulet and its variants work against them. Arclight and its variants as well as Holy water do not work against them.
- Abyssal Sire (Abyssal demon)
- K'ril Tsutsaroth (Greater demon, Holy water does not work)
- Skotizo (Black demon, Greater demon)
- ↑ Only harmed by Flames of Zamorak, which indirectly means arclight and its variants as well as Holy water do not work.
- Jungle Demon
- Kolodion (Black demon, final form only)
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