Old School RuneScape Wiki

Sanfew serum detail.png

Sanfew serum combines the properties of Super restore, Superantipoison, and Relicym's balm (though, unlike the latter, will provide immunity to disease when consumed) potions. The duration of the antipoison lasts six minutes, the same time as a Superantipoison does.

Level 65 Herblore and completion of Zogre Flesh Eaters is required in order to make this potion.

A complete Sanfew serum can be used as a weapon against nail beasts, causing significant damage. To use it as a weapon, right-click on the potion and select use, then click on a nail beast. This should be done if a nail beast is attacking the follower in Temple Trekking.

The amount of prayer points restored by a sanfew serum can be calculated using the formula: . A sanfew serum restores one more prayer point per dose than a super restore.


Sanfew serum is made by adding, in order, unicorn horn dustclean snake weed and nail beast nails to an already made 4 dose Super restore. Partially completed Sanfew serums are called Mixture - step 1 and Mixture - step 2, but are not drinkable in these forms.

Players therefore need to make sure that the unicorn horn dust is highlighted before clicking each of the vials to avoid accidentally drinking any of the super restore. Since the intermediate potions are not drinkable, the same danger does not exist once the unicorn horn dust has been added.

96 Herblore experience is given for a completed 1-dose Sanfew serum, 128 experience for a completed 2-dose Sanfew serum, 160 experience for a completed 3-dose Sanfew serum, or 192 experience for a completed 4-dose Sanfew serum.

Price per dose

Item Price per dose
Sanfew serum(1).png Sanfew serum(1) 7,009
Sanfew serum(2).png Sanfew serum(2) 7,228
Sanfew serum(3).png Sanfew serum(3) 7,738
Sanfew serum(4).png Sanfew serum(4) 7,724

Dropping monsters

Note: The monsters below drop the potion in 4 dose vials.

Monster Combat level Quantity Rarity
Kraken 291 2 3; Uncommon
Thermonuclear smoke devil 301 2 3; Uncommon
Vet'ion 454 10 (noted) 3; Uncommon

Production costs

Material Material cost Profit Profit/XP
Super restore(1).png Super restore(1) 15,911 −8,902 −92.73
Super restore(2).png Super restore(2) 18,291 −3,835 −29.96
Super restore(3).png Super restore(3) 20,851 2,364 14.78
Super restore(4).png Super restore(4) 23,334 7,560 39.38