Skull could refer to any of the following:
- Animal skull, one of 2 quest items
- Monkey skull, a rare item that can be used to make a blue face gorilla Greegree
- Muddy skull, a quest item
- Skull (item), an item with various uses
- Skull (status), a status that affected items kept on death
- Skull sceptre, a player-made staff that is able to teleport to Barbarian Village
- Strange skull, one of the components required to make the staff
- Right skull half, an item used to make the full skull
- Left skull half, an item used to make the full skull
- Skull Torch, a decoration a player can build in their POH
- Werewolf Skullball, an Agility related activity
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