Use Protect from Missiles, and attack with Ranged. Vespula can poison players starting at 20 damage, so a Serpentine helmet or another form of poison protection is highly recommended. In addition, septic tentacles will spawn near the entrance, dealing moderate poison damage (will not cause poison) to those who pass it once the fight starts.
The chamber contains lux grubs, which need to be fed medivaemia blossoms, which are also found in the same chamber. The grubs have a health bar, which will constantly degrade. If their health reaches 0, they will turn into vespine soldiers, fully healing both Vespula and the portal. For this reason, it is recommended that at least one member of the team focuses solely on feeding blossoms to the grubs.
When Vespula reaches 20% of its health, she will stop flying, and can only be harmed with melee. During this time, the team should focus their attacks on the abyssal portal. Enchanted ruby bolts can be very effective against the portal. After a short time, Vespula will go back to flying, and the team should refocus on her. While it is possible to attack the portal at any time, it will cause Vespula to become enraged, using her stinger to attack anyone nearby for high damage. This can be avoided by staying away from melee distance or going under her, though doing the latter will cause rapid stomp damage of up to 8 per tick instead.
When the portal is destroyed, Vespula and the lux grubs will fall with it, ending the encounter.
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